Stochasticity in Physiologically Based Kinetics Models: Implications for Cancer Risk Assessment
نویسندگان
چکیده
منابع مشابه
Stochasticity in physiologically based kinetics models: implications for cancer risk assessment.
In case of low-dose exposure to a substance, its concentration in cells is likely to be stochastic. Assessing the consequences of this stochasticity in toxicological risk assessment requires the coupling of macroscopic dynamics models describing whole-body kinetics with microscopic tools designed to simulate stochasticity. In this article, we propose an approach to approximate stochastic cell c...
متن کاملPhysiologically based pharmacokinetics and cancer risk assessment.
Physiologically based pharmacokinetic (PBPK) modeling involves mathematically describing the complex interplay of the critical physicochemical and biological determinants involved in the disposition of chemicals. In this approach, the body is divided into a number of biologically relevant tissue compartments, arranged in an anatomically accurate manner, and defined with appropriate physiologica...
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Post-exposure risk assessment of chemical and environmental stressors is a public health challenge. Linking exposure to health outcomes is a 4-step process: exposure assessment, hazard identification, dose response assessment, and risk characterization. This process is increasingly adopting "in silico" tools such as physiologically based pharmacokinetic (PBPK) models to fine-tune exposure asses...
متن کاملDevelopment and specification of physiologically based pharmacokinetic models for use in risk assessment.
Risk assessments are performed to estimate the conditions under which individuals or populations may be harmed by exposure to environmental or occupational chemicals. In the absence of quantitative data in the human, this process is often dependent upon the use of animal and in vitro data to estimate human response. To reduce the uncertainty inherent in such extrapolations, there has been consi...
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BACKGROUND A physiologically based pharmacokinetic (PBPK) model would make it possible to simulate the dynamics of chemical absorption, distribution, metabolism, and elimination (ADME) from different routes of exposures and, in theory, could be used to evaluate associations between exposures and biomarker measurements in blood or urine. OBJECTIVE We used a PBPK model to predict urinary excret...
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ژورنال
عنوان ژورنال: Risk Analysis
سال: 2009
ISSN: 0272-4332,1539-6924
DOI: 10.1111/j.1539-6924.2009.01242.x